NCT02868385

Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST)

Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST): An Open Label, Randomized Controlled Trial of Single vs. Multiple Treatments of Praziquantel in Intestinal African Schistosomiasis in Côte d'Ivoire

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 167 (actual)
• Sponsor: Leiden University Medical Center · Academic / Other
• Sex: All
• Age: 5 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

An open label, randomized controlled trial of single vs. multiple treatments of praziquantel in intestinal African schistosomiasis in Côte d'Ivoire This study aims to determine the efficacy of repeated (up to four times) praziquantel treatment against S. mansoni infection in school-age children from Côte d'Ivoire using the traditional Kato-Katz thick smear technique, but also with more accurate and non-invasive antigen- and DNA-detection methods.

Conditions

• Schistosomiasis

Interventions

Type	Name	Description
DRUG	4x Praziquantel	Four consecutive praziquantel treatments (40 mg/kg): at baseline (week 0) and at week 2, 4, and 6.
DRUG	1x Praziquantel	One praziquantel treatment (40 mg/kg) at baseline

Timeline

• Start date: 2018-10-01
• Primary completion: 2019-01-14
• Completion: 2019-01-14
• First posted: 2016-08-16
• Last updated: 2020-11-18

Locations

1 site across 1 country: Côte d’Ivoire