NCT02863380

Personalized rTMS for Resistant Depression

Validation of Personalized Antidepressant Treatment by Neuromodulation - Pilot Study

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that personalizing the rTMS targets using functional MRI will increase its efficacy. The most dysfunctional regions or the most dysfunctional network will be stimulated homogeneously. Individualized rTMS will be compared to traditional rTMS procedure and to trans-cranial direct current stimulation (tDCS) in a randomized cross-over trial. In this pilot study the primary outcome measure will be the correction of the MRI anomalies. Symptoms reduction and the proportion of remitters will be secondary outcome measurements.

Conditions

• Depressive Disorder
• Treatment-Resistant

Interventions

Type	Name	Description
PROCEDURE	Functional magnetic resonance imaging used to individualize rTMS protocol	Procedure consisting in personalizing the rTMS targets and stimulation pattern based on functional magnetic resonance imaging
DEVICE	Individualized rTMS (transcranial magnetic stimulation)
DEVICE	Classical rTMS (transcranial magnetic stimulation)
DEVICE	Classical tDCS (transcranial direct current stimulation)

Timeline

• Start date: 2016-05-04
• Primary completion: 2021-01-21
• Completion: 2021-01-21
• First posted: 2016-08-11
• Last updated: 2025-09-24

Locations

1 site across 1 country: France