NCT02848482

Anti-infective Effect of Non-surgical Treatment With and Without Photodynamic Therapy on Initial Peri-implantitis

Anti-infective Effect of Non-surgical Treatment With and Without Photodynamic

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Photodynamic therapy (PDT), also known as photoradiation therapy, phototherapy, or photochemotherapy, involves the use of a photoactive dye (photosensitizer) that is activated by exposure to light of a specific wavelength in the presence of oxygen. In recent years, PDT has been introduced as an important novel disinfection therapy in the field of implant dentistry. The inactivation of microorganisms using PDT has been defined as antimicrobial PDT. PDT has the potential to be an alternative of antibiotics, especially for the treatment of localized infections and oral biofilm. PDT is unlikely to cause bacterial-resistance and is equally effective against antibiotic-resistance and antibiotic-susceptible bacteria. Inconsistent results have been reported regarding the potential role of PDT as an adjunct to mechanical debridement in the management of peri-implant infection. Thus, the aim of the present trial is to investigate the treatment effect of non-surgical treatment with and without photodynamic therapy on initial peri-implantitis.

Conditions

• Peri-implantitis

Interventions

Type	Name	Description
DEVICE	Photodynamic therapy	Photodynamic therapy (HELBO Photodynaimc Systems GmbH, Wels, Austria)
PROCEDURE	Mechanical debridement	Plastic scalers (Have implantrecallset, Kerr, Italy) will be used to curette the contaminated sites.
DRUG	Irrigation	0.2% chlorhexidine digluconate solution (Bioworld, Madision, US) will be irrigated at contaminated sites for 1 minute.

Timeline

• Start date: 2017-05-01
• Primary completion: 2019-05-01
• Completion: 2019-05-01
• First posted: 2016-07-28
• Last updated: 2019-05-16

Locations

1 site across 1 country: China