NCT02826174

Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Wenzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Penetrating keratoplasty (PKP) is an open-sky surgery that fundamentally has not changed for more than 100 years. Because conventional PKP is associated with the potential for the development of devastating complications such as expulsive suprachoroidal hemorrhage and endophthalmitis, we modified the technique to one that is a closed surgery under topical anesthesia with the anterior chamber maintained to achieve favorable results. Topical anesthesia is an attractive alternative to traditional injection local anesthesia since the potentially serious complications associated with retrobulbar and peribulbar anesthesia can be avoided. The closed PKP procedure with the stable anterior chamber essentially changes the open nature of conventional PKP. The advantages, i.e., decreased surgical risks, postoperative complications, and surgical difficulties, make PKP viable in most complicated cases.

Conditions

• Corneal Opacity
• Keratitis, Herpetic
• Corneal Ulcer
• Corneal Dystrophies, Hereditary

Interventions

Type	Name	Description
PROCEDURE	closed PKP under topical anesthesia	a closed corneal transplantation under topical anesthesia with the anterior chamber maintained
PROCEDURE	open-sky PKP under retrobulbar anesthesia	an open-sky corneal transplantation under retrobulbar anesthesia
DRUG	Anti-Rejection Agents	Anti-Rejection Agents for both groups
DRUG	Anti-Inflammatory Agents	Anti-Inflammatory Agents for both groups

Timeline

• Start date: 2015-12-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2016-07-07
• Last updated: 2016-07-07

Locations

1 site across 1 country: China