NCT02813954

The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 184 (actual)
• Sponsor: Kanuni Sultan Suleyman Training and Research Hospital · Academic / Other
• Sex: All
• Age: 25 Hours
• Healthy volunteers: Accepted

Summary

Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress. While fetal urine is the major content of AF since 20th gestational week, fetal lung liquid (FLL) also acts as a minor content. Secretion of FLL depends on chloride transport and postnatal clearance of FLL is provided by active reabsorption of sodium (Na) ions. Down-regulation of epithelial Na channels (ENaCs) and an increase of pulmonary compliance accompany to pulmonary adaptation developing at the first hours of life. Lower genomic expression of Na channels in airways is shown to be associated to respiratory distress syndrome (RDS) in preterm. Although pH and electrolyte value of AF is thought to be relevant to fetal and maternal conditions such as gestational age, antenatal steroids and preterm birth, there is no study about this topic in the literature.

Conditions

• Respiratory Distress Syndrome
• Transient Tachypnea of Newborn

Interventions

Type	Name	Description
DEVICE	Blood Gas Sampling	analyzing amniotic fluid by blood gas device

Timeline

• Start date: 2015-08-01
• Primary completion: 2016-04-01
• Completion: 2016-04-01
• First posted: 2016-06-27
• Last updated: 2022-08-18