Trials / Completed
CompletedNCT02812901
Tolerance of Myocardium to Ischemia Injury
Morning / Afternoon Variation in Myocardial Ischemia Tolerance
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 88 (actual)
- Sponsor
- University Hospital, Lille · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | cardiac surgery scheduled in the morning | cardiac surgery scheduled in the morning |
| PROCEDURE | cardiac surgery scheduled in the afternoon | cardiac surgery scheduled in the afternoon |
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2017-07-01
- Completion
- 2017-07-01
- First posted
- 2016-06-24
- Last updated
- 2026-02-05
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02812901. Inclusion in this directory is not an endorsement.