NCT02782208

Lipolytic Effects of GH in Hypopituitary Patients in Vivo

Lipolytic Effects of GH in Hypopituitary Patients in Vivo: Molecular Mechanisms and Temporal Patterns.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Growth hormone (GH) is essential for longitudinal bone growth and somatic development. These protein anabolic effects require sufficient nutritional supply. During fasting and caloric restriction GH predominantly promotes fat metabolism. GH counteracts the effect of insulin in many tissues, of which insulin-stimulated glucose uptake in skeletal muscle has been most extensively studied. Substrate competition between elevated free fatty acids and glucose is suggested as a mechanism, and this hypothesis can be tested mechanistically by means of acipimox, which is a nicotinic acid that suppresses the fat metabolizing effects of GH. The hypothesis is, that the suppressive effect of GH on insulin-stimulated glucose uptake in skeletal muscle is obviated by acipimox-induced inhibition of fat metabolism. In order to investigate this, eight adult hypopituitary patients with documented GH-deficiency will be studied in the presence and absence of GH and acipimox, respectively, and biopsies from skeletal muscle and subcutaneous adipose tissue will be analyzed. Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in long-sight have great importance for the understanding of growth disorders from overweight and type 2 diabetes to malnutrition and eating disorders.

Conditions

• Hypopituitarism
• Insulin Resistance
• Endocrine System Diseases
• Glucose Metabolism Disorders
• Metabolic Diseases
• Pituitary Diseases
• Brain Diseases

Interventions

Type	Name	Description
DRUG	Acipimox	Acipimox is administered 4 times previous to and during the investigation day. Acipimox is used to suppress the lipolytic effect of GH.
DRUG	Placebo	Placebo is administered 4 times previous to and during the investigation day.
DRUG	GH substitution	GH substitution as usually
OTHER	GH pause	GH substitution pause two days prior to the experimental day

Timeline

• Start date: 2016-02-10
• Primary completion: 2016-12-22
• Completion: 2016-12-22
• First posted: 2016-05-25
• Last updated: 2020-03-26

Locations

1 site across 1 country: Denmark