NCT02776514

Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis

Intraarticular Injections of Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Balgrist University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study investigates clinical outcome and imaging outcome parameters after intraarticular injection of steroids, platelet-rich-plasma (prp), hyaluronic acid or placebo in patients with early osteoarthritis of the knee joint.

Detailed description

Osteoarthritis of the knee joint is a very common disease in middle aged and elderly patients. This study evaluates the efficiency of different commonly used substances for intraarticular, non-operative treatment in early stages of this disease. 120 patients receive an fluoroscopic guided injection in the knee joint: 30 patients get injection with steroids 30 patients get injection with prp 30 patients get injection with hyaluronic acid 30 patients get injection with placebo (iopamiro contrast media) Primary outcome: - clinical outcome (pain using numeric rating scale) * Magnetic Resonance imaging (cartilage defects etc.)

Conditions

• Osteoarthritis, Knee

Interventions

Type	Name	Description
DRUG	Triamcort	Fluoroscopic guided injection in the knee joint
DRUG	Platelet-rich-plasma
DRUG	Suplasyn1
DRUG	Placebo

Timeline

• Start date: 2016-02-01
• Primary completion: 2020-11-01
• Completion: 2020-11-01
• First posted: 2016-05-18
• Last updated: 2022-02-07

Locations

1 site across 1 country: Switzerland