NCT02772900

Aging, Nitrate, Endothelial Function and Muscle Oxygenation

Effect of a Beetroot-based Nutritional Gel on Vascular Function and Forearm Muscle Oxygenation Responses in the Elderly at Cardiometabolic Risk

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Universidade Federal do Rio de Janeiro · Academic / Other
• Sex: All
• Age: 65 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Aging has been associated with reduced bioavailability of nitric oxide (NO) and endothelial dysfunction. Beetroot consumption, a nitrate-rich food, has been associated with increased NO bioconversion, which may promote beneficial effects on vascular health. The present study evaluated the effects of a beetroot-based nutritional gel (BG) on vascular function, arterial stiffness and blood pressure in the elderly at cardiometabolic risk. Twenty elderly individuals were submitted to BG and nitrate-depleted gel (PLA) interventions. Brachial flow-mediated dilation (FMD), blood flow velocity (BFV), peak wave velocity (PWVβ), augmentation index (AI), stiffness parameter (β), pressure-strain elasticity modulus (Ep), arterial compliance (AC), muscle oxygenation and function were measured 90 min after interventions. Urinary nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline, 90 min and 150 min after interventions.

Conditions

• Aging
• Hypertension
• Dyslipidemia
• Abdominal Obesity

Interventions

Type	Name	Description
OTHER	Beetroot-based nutritional gel	100 g of beetroot-based nutritional gel containing approximately 12 mmol of nitrate.
OTHER	Placebo	100 g of apple-based nutritional gel containing approximately 0.02 mmol of nitrate.

Timeline

• Start date: 2015-05-01
• Primary completion: 2015-11-01
• Completion: 2016-01-01
• First posted: 2016-05-16
• Last updated: 2016-05-17