NCT02769910

Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch

The Role of Pre-established Skin Inflammation on the Susceptibility to Histamine and Cowhage-induced Itch in Healthy Humans

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Hjalte Holm Andersen · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage. The hypothesis is that capsaicin-induced pre-established neurogenic inflammation significantly increases susceptibility to itch provocations with cowhage and histamine.

Conditions

• Pruritus

Interventions

Type	Name	Description
DRUG	Capsaicin 24 Hours	Dermal patches for transdermal application of Capsaicin, applied for 24 hours
DRUG	Capsaicin 1 Hour	Dermal patches for transdermal application of Capsaicin, applied for 1 hour
OTHER	Qutenza Demo Patch	Dermal patches mimicking active Qutenza patches. Used as control in comparison of Capsaicin efficacy. Applied for 24 hours.

Timeline

• Start date: 2016-05-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2016-05-12
• Last updated: 2016-11-22

Locations

1 site across 1 country: Denmark