NCT02766946

Diaphragmatic Atrophy Related to Mechanical Ventilation

Ultrasound Observation of Diaphragmatic Atrophy Related to Mechanical Ventilation A Prospective Monocentric Study in Intensive Care Unit

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 97 (actual)
• Sponsor: Centre Hospitalier Saint Joseph Saint Luc de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Ventilatory support during critical phase result in inactivity of respiratory muscles especially diaphragm muscle. These inactivity also result in change of contractile capability and quick muscular atrophy. The aim of the study is to visualize the evolution of diaphragm thickness by echography during Mechanical Ventilation for patients with septic shock or acute respiratory distress syndrome and to compare with the evolution for patients under non-invasive ventilation and those with spontaneous ventilation. Measurements will be performed at day 1, day 5 and day 10 (if patient still under a mode of ventilation or in the unit). The evolution of diaphragm thickness will also be compared to pectoralis muscle atrophy, which is not involved in ventilation, in order to assess respective effect of ventilatory inactivity and undernutrition linked to intensive care.

Conditions

• Septic Shock
• Acute Respiratory Distress

Interventions

Type	Name	Description
DEVICE	Ultrasound	An ultrasound of the right diaphragm will be performed on day 1, day 3, day 5 and day 10
DEVICE	Ultrasound	An ultrasound of the pectoral muscle will be performed on day 1, day 3, day 5 and day 10
OTHER	Neuromyopathy score	A neuromyopathy score will be assessed on the extubation day
OTHER	Respiratory performances	An assessment of the respiratory performances will be done on the extubation day, including higher expiratory pressure, higher inspiratory pressure, and occlusion pressure

Timeline

• Start date: 2013-06-24
• Primary completion: 2015-12-17
• Completion: 2015-12-22
• First posted: 2016-05-10
• Last updated: 2024-04-04