Trials / Completed
CompletedNCT02765347
The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM
The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM: A Randomized, Cross-over, Prospective Study
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 30 (actual)
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University · Academic / Other
- Sex
- All
- Age
- 12 Years
- Healthy volunteers
- Not accepted
Summary
The investigators intends to carry out a randomized, cross-over, prospective study which will last 48 weeks in youth with T1DM followed up by the center. The purpose is to observe the effects of metformin on glycemic control and insulin sensitivity in adolescents with T1DM based on insulin therapy by using 72h CGMS and hyperinsulinemic euglycemic clamps.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Metformin | For arm 1, accept MDI or CSII plus metformin (initially starting dosage with 0.5g qd, then gradually increasing to 0.5g tid) for 24 weeks. |
| DRUG | Insulin | For arm 2, just accept insulin for 24 weeks |
Timeline
- Start date
- 2016-06-01
- Primary completion
- 2018-01-01
- Completion
- 2018-01-01
- First posted
- 2016-05-06
- Last updated
- 2018-04-12
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT02765347. Inclusion in this directory is not an endorsement.