Trials / Completed
CompletedNCT02758470
Muscle Fatigue and Carbonic Anhydrase Inhibitors
The Effect of Carbonic Anhydrase Inhibitors on the Pulmonary System Response to Muscle Fatigue.
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 13 (actual)
- Sponsor
- University of British Columbia · Academic / Other
- Sex
- Male
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Acetazolamide | 250 mg, taken orally three times per day |
| DRUG | Methazolamide | 100mg, taken orally two times per day. A placebo pill will be taken between each dose of methazolamide to match the timing of doses and the number of pills between study arms. |
| OTHER | Placebo | A placebo will be taken three times per day |
Timeline
- Start date
- 2016-11-01
- Primary completion
- 2017-06-30
- Completion
- 2017-06-30
- First posted
- 2016-05-02
- Last updated
- 2018-09-25
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT02758470. Inclusion in this directory is not an endorsement.