Trials / Completed
CompletedNCT02738671
Relationship Between Diabetes and Cognitive Impairment Based on Olfactory Function Assessment and Functional MRI
The Cross-sectional and Longitudinal Study of Relationship Between Diabetes and Cognitive Impairment by Olfactory Function Assessment and Functional MRI in Obese and Normal Weight Diabetic Patients
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 250 (actual)
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Academic / Other
- Sex
- All
- Age
- 30 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to explore the relationship between diabetes and cognitive impairment by olfactory function assessment and functional MRI.
Detailed description
Previous research has shown both obesity and diabetes are associated with an increased risk of cognitive impairment. Meanwhile, olfactory impairment is associated with incident (amnestic mild cognitive impairment) aMCI and progression from aMCI to (Alzheimer disease) AD dementia. On one hand, in the cross-sectional study, biometric measurements, cognitive assessment, olfactory function and fMRI results are analysed to explore the differences among T1DM patients, T2DM patients and non-diabetic people . One the other hand, in the longitudinal study, changes in olfactory function and fMRI results in diabetic and non-diabetic obese patients both at baseline and 6 months after their bariatric surgery are collected to investigate whether better glucose and weight control benefit brain function.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Cognitive assessment | |
| OTHER | functional magnetic resonance imaging | |
| OTHER | olfactory function measurement | |
| PROCEDURE | bariatric surgery | Only a subgroup of the subjects will have the bariatric surgery. |
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2019-03-01
- Completion
- 2019-05-01
- First posted
- 2016-04-14
- Last updated
- 2019-05-30
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT02738671. Inclusion in this directory is not an endorsement.