NCT02727465

Host-pathogen Interactions in Meningococcal Disease: Finding the Key That Fits the Lock

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Public Health England · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

At any time, around 10% of people carry meningococcal bacteria in the nose and throat, which can cause meningitis, blood poisoning and other serious illnesses. Most people carry these bacteria and never become ill, yet a very small proportion go on to develop these illnesses which can result in life long disabilities or death. The mechanism by which this happens is poorly understood and has been studied in various ways, usually focussing on the bacteria or on the individual, but none has given a definitive answer. This study will be the first of its kind and will assess the interaction between the host and the bacteria at the genetic level, through genetic mapping, helping us to understand what makes some people susceptible to this infection.

Detailed description

At any time, around 10% of people carry meningococcal bacteria in the nose and throat, which can cause meningitis, blood poisoning and other serious illnesses. Most people carry these bacteria and never become ill, yet a very small proportion go on to develop these illnesses which can result in life long disabilities or death. The mechanism by which this happens is poorly understood and has been studied in various ways, usually focussing on the bacteria or on the individual, but none has given a definitive answer. This study will be the first of its kind and will assess the interaction between the host and the bacteria at the genetic level, through genetic mapping, helping us to understand what makes some people susceptible to this infection.

Conditions

• Meningitis

Interventions

Type	Name	Description
OTHER	Meningitis cases	None - blood draw only

Timeline

• Start date: 2016-03-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2016-04-04
• Last updated: 2017-04-05

Locations

1 site across 1 country: United Kingdom