NCT02724501

Studies of the Tumour Suppressor Gene PTEN - Endometrial Cancer

Clinical and Molecular Studies of the Tumour Suppressor Gene PTEN in Endometrioid Type Endometrial Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 217 (actual)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to understand the role of the PTEN tumour suppressor gene in endometrial cancer (tumours of the uterine lining), the most common gynecologic cancer in the developed world. The studies in this program span the spectrum from fruit flies to humans, as part of a synergistic partnership that will significantly enhance our understanding of the molecular genetic events involved in the development and progression of endometrial cancer. The discovery of new targets for therapy, and the ability to evaluate these in subsequent clinical trials is a significant strength of this scientific interaction, which may result in cures for patients with primary and relapse endometrial cancer and prevention of this cancer in women who are at high risk.

Detailed description

PTEN is a critical module that regulates effects of sex hormones on the growth and apoptosis of endometrial cells; and plays an important role in the pathogenesis of subgroups of endometrial cancers, their biologic behaviour and responses to therapeutic agents. Furthermore, mutational inactivation of the PTEN gene can serve as an independent molecular marker that can predict relapse and survival in endometrial cancer. The prognostic effects of PTEN may also be modulated by other tumour suppressor gene losses including P53 mutations, by hormone receptor status, and microsatellite instability.

Conditions

• Endometrial Neoplasms

Interventions

Type	Name	Description
BEHAVIORAL	questionnaire	Using questionnaire to obtain patient's medical and family history of cancer.
PROCEDURE	Blood sample-DNA testing / Tumour-genetic markers	Using Samples obtained to produce summary statistics on the tumour markers

Timeline

• Start date: 2000-04-01
• Primary completion: 2011-10-01
• Completion: 2011-10-01
• First posted: 2016-03-31
• Last updated: 2016-03-31

Locations

1 site across 1 country: Canada