NCT02711982

Surgery for Traumatic Optic Neuropathy

Clinical Treatment of Traumatic Optic Neuropathy: Optic Nerve Decompression Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (estimated)
• Sponsor: Shanghai Changzheng Hospital · Academic / Other
• Sex: All
• Age: 10 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The pathophysiology of Traumatic Optic Neuropathy (TON) include a primary and secondary mechanism of injury. At present, no studies validate a particular approach to the management of TON. There are three management lines for these patients that include 1)observation only;2)medical treatment with high or megadoses of methylprednisolone; and 3)surgical intervention. Studies have shown that forces applied to the frontal bone and malar eminences are transferred and concentrated in the area near the optic canal. The tight adherence of the optic nerve's dural sheath to the periosteum within the optic canal is also thought to contribute to this segment of the nerve being extremely susceptible to the deformative stresses of the skull bones. In this study, investigators aim to make a randomized controlled trial to certify the efficiency of optic nerve canal decompression for TON patients.

Detailed description

surgical intervention's efficiency and outcome for TON patients will be clearly present after this randomized controlled trial study.

Conditions

• Traumatic Optic Neuropathy

Interventions

Type	Name	Description
PROCEDURE	Optic canal and optic nerve sheath decompression	within 5 days from trauma
DRUG	methylprednisolone	within 5 days from trauma

Timeline

• Start date: 2010-01-01
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2016-03-17
• Last updated: 2016-03-17

Locations

1 site across 1 country: China