NCT02708394

Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

Molecular Mechanisms of Antipsychotic-induced Insulin Resistance in Healthy Volunteers

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Wayne State University · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.

Conditions

• Adverse Effect of Other Antipsychotics and Neuroleptics
• Insulin Resistance

Interventions

Type	Name	Description
DRUG	olanzapine	atypical antipsychotic
DRUG	placebo	placebo control

Timeline

• Start date: 2017-02-01
• Primary completion: 2023-10-01
• Completion: 2023-10-01
• First posted: 2016-03-15
• Last updated: 2023-10-31

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study