Trials / Terminated
TerminatedNCT02702167
High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Bulimia and Anorexia Nervosa
The Dorsomedial Prefrontal Cortex as a Target in Treatment-resistant Bulimia Nervosa and Anorexia Nervosa: Investigating Target Engagement, Dosing, Reliability and Duration of Effect Using rTMS, fMRI, and a Sham Controlled Arm
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 90 (actual)
- Sponsor
- University Health Network, Toronto · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
This trial will compare the efficacy and tolerability of 10 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered once daily over 30 days, in patients with a diagnosis of bulimia or anorexia nervosa binge-purge subtype. The trial will include structural and functional MRI, and behavioral measures obtained before, during, and after treatment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | High-frequency rTMS | 10 Hz active stimulation, once daily |
| DEVICE | Low-frequency rTMS | 1 Hz active stimulation, once daily |
| DEVICE | Sham rTMS | Sham stimulation, once daily |
Timeline
- Start date
- 2017-11-01
- Primary completion
- 2021-04-30
- Completion
- 2021-04-30
- First posted
- 2016-03-08
- Last updated
- 2021-09-29
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT02702167. Inclusion in this directory is not an endorsement.