NCT02701764

Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Can Lyrica (Pregabalin) help prevent severe Dry Eye post LASIK surgery?

Detailed description

Dry eye symptoms can occur after LASIK surgery. They generally get better with time but in some patients, they can persist. The investigators believe that in some individuals, dry eye symptoms after LASIK persist because the nerves in the cornea become hypersensitive. The investigators wish to study if a medication, called pregabalin, can protect corneal nerves at the time of LASIK surgery and decrease the frequency and severity of dry eye symptoms 6 months after surgery. This medication has been used in a similar way to reduce the frequency of uncomfortable sensations after other surgeries (knee, abdomen) but has never been studied in LASIK surgery.

Conditions

• Dry Eye

Interventions

Type	Name	Description
DRUG	Pregabalin
DRUG	Placebo

Timeline

• Start date: 2016-07-26
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2016-03-08
• Last updated: 2019-11-14
• Results posted: 2019-08-28

Locations

1 site across 1 country: United States