NCT02694705

Assessment of Preoxygenation Strategies in the Prehospital Environment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Queen Mary University of London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.

Detailed description

Prospective randomised interventional study. Healthy volunteers will be positioned supine and undergo preoxygenation by tidal volume breathing for 3 minutes using each technique in turn. The sequence of techniques for each volunteer will be randomised in advance. Investigators will be instructed to ensure a good mask seal throughout the testing period. At the end of a 3 minute preoxygenation period, after a brief breath hold, the volunteer will exhale into reservoir tubing, allowing the fractional expired oxygen concentration (FeO2) to be determined (primary outcome) using a calibrated gas analyser. The techniques being assessed have been chosen from methods of preoxygenation commonly available to clinicians in the prehospital environment: 1. Continuous Positive Airway Pressure mode with fractional inspired oxygen concentration (FiO2) 100% using a portable ventilator. 2. Bag-valve-mask device (BVM) with 15 l/min oxygen flow. 3. Non-rebreather mask (NRM) device with 15 l/min oxygen flow. Volunteers will also be asked to indicate the subjective ease of breathing for each technique (secondary outcome) using a visual analogue scale (VAS).

Conditions

• Anesthesia
• Hypoxia

Interventions

Type	Name	Description
DEVICE	Continuous Positive Airway Pressure (CPAP)	CPAP provided by a portable Draeger Oxylog® 3000 plus ventilator
DEVICE	Bag-Valve-Mask (BVM)	Preoxygenation provided by BVM device, oxygen flow rate 15 l/min
DEVICE	Non-rebreather Mask (NRM)	Preoxygenation provided by NRM, oxygen flow rate 15 l/min

Timeline

• Start date: 2016-02-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2016-02-29
• Last updated: 2016-09-30

Locations

1 site across 1 country: United Kingdom