NCT02676427

Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination

Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination - "FRIEND Study"

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Charles University, Czech Republic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aims at clarification of venous collapsibility measures with real venous flow measurements during dynamic maneuver testing fluid responsiveness in septic shock patients.

Detailed description

Sedated and mechanically ventilated patients in septic shock will be enrolled in the study. A fine catheter with ultrasound doppler probe will be introduced into the central venous catheter already in place in superior vena cava. Doppler signal will be evaluated by console prototype (NILUS Medical) and continuous analysis of blood flow velocity respiratory variation will be performed. These values will be compared to standard hemodynamic monitoring parameters (central venous and arterial pressures) and to parameters acquired by transoesophageal (TOE) and transthoracic echocardiography.

Conditions

• Septic Shock
• Vein Collapsibility
• Intravascular Doppler
• Volume Responsiveness in Septic Shock

Interventions

Type	Name	Description
PROCEDURE	passive leg raising	passive leg raising under echocardiographic monitoring with intravascular doppler in place

Timeline

• Start date: 2015-09-01
• Primary completion: 2021-05-01
• Completion: 2021-06-01
• First posted: 2016-02-08
• Last updated: 2019-08-02

Locations

1 site across 1 country: Czechia