NCT02652832

Effects of Noninvasive Brain Stimulation Techniques on BDNF Levels

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Hôpital le Vinatier · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate the effects of non invasive brain stimulation - NIBS - techniques (Electroconvulsivotherapy - ECT, transcranial Direct Current Stimulation - tDCS, repetitive transcranial magnetic stimulation - rTMS) on serum Brain Derived Neurotrophic factor (BDNF) levels in patients with depression and schizophrenia. Four blood samples will be collected in each participants, one before the NIBS sessions, and 3 after the completion of NIBS protocols: one immediately after the end of the NIBS sessions, a second one week after and a last one month after. Two blood samples separated by one month will also be collected in a a group of healthy volunteers.

Detailed description

The hypothesis is that NIBS will modulate BDNF levels and that the modification in serum BDNF levels will be correlated with clinical improvements in the sample of patients.

Conditions

• Depression
• Schizophrenia

Interventions

Type	Name	Description
DEVICE	non invasive brain stimulation	non invasive brain stimulation

Timeline

• Start date: 2010-12-01
• Primary completion: 2018-12-31
• Completion: 2019-06-30
• First posted: 2016-01-12
• Last updated: 2018-08-01

Locations

1 site across 1 country: France