NCT02648932

The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients

The Rapid Study: Randomized (RA) Phase (P) II Study To Expedite Allogeneic Transplant With Immediate (I) Haploidentical Plus Unrelated Cord Donor (D) Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study seeks to compare time from formal search to hematopoietic cell transplantation (HCT) for patients 18 years and older, randomized between haplo-cord search and matched unrelated donor (MUD) search for patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)

Detailed description

Primary Objectives To compare time from formal search to hematopoietic cell transplantation (HCT) for patients 18 years and older, randomized between haplo-cord search and matched unrelated donor (MUD) search for patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) Secondary Objectives * To compare the percentage of patients who undergo HCT in each study cohort * To evaluate overall survival from time to randomization by study cohort

Conditions

• Acute Myeloid Leukemia (AML)
• Myelodysplastic Syndrome (MDS)

Interventions

Type	Name	Description
BIOLOGICAL	Haplo-Cord Transplant	For conditioning regimens, haplo-identical grafts will be selected by the Miltenyi Device
PROCEDURE	Matched Unrelated Donor Transplant

Timeline

• Start date: 2016-02-04
• Primary completion: 2020-04-01
• Completion: 2020-04-01
• First posted: 2016-01-07
• Last updated: 2021-03-18
• Results posted: 2021-03-18

Locations

1 site across 1 country: United States