NCT02640586

Predicting Neoadjuvant Therapy Response of Rectal Cancer With MRI

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,614 (actual)
• Sponsor: Sun Ying-Shi · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate if MRI scans performed after neoadjuvant radiotherapy can predict the therapeutic response of rectal cancer following preoperative chemo-radiotherapy. This will help doctors to better tailor treatments for rectal cancer in the future.

Detailed description

We proposed to constructed multi-parameter predictive model for predicting therapeutic response and pathological complete response(pCR) of patients with rectal cancer who received neoadjuvant chemoradiation. MR radiomics,convolutional neural networks, morphological parameters and quantitative functional parameters derived from diffusion-weighted MR images will be integrated for model construction.

Conditions

• Rectal Neoplasms

Interventions

Type	Name	Description
DEVICE	three MR examination	Three MR examinations: first MRI taken within 1 week before preoperative chemo-radiotherapy; second MRI taken between 14-16days after the initiation of radio-chemotherapy; third MRI taken 7-9 weeks after the completion of preoperative chemo-radiotherapy.

Timeline

• Start date: 2016-01-10
• Primary completion: 2020-07-17
• Completion: 2023-12-31
• First posted: 2015-12-29
• Last updated: 2023-06-22

Locations

11 sites across 1 country: China