NCT02633488

Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to look at how insulin (a hormone that helps the cells get energy from sugar) in our body affects blood vessels (elasticity in the bigger blood vessels and blood flow in the smaller blood vessels in the arm) and how Metformin (a drug that makes you more sensitive to insulin) affects insulin's action on the blood vessels.

Detailed description

In our protocol, we will study vascular function using pulse wave velocity (PWV) augmentation index (AI), flow mediated dilation (FMD) and contrast enhanced ultrasound (CEU) as well as insulin sensitivity (euglycemic clamp) in 50 adults with metabolic syndrome, age 18-60 years. They will each be studied 4 times,before and after two 12-wk interventions (randomly assigned) as follows: 1) Placebos and 2) Metformin . This is a cross-over design.

Conditions

• Metabolic Syndrome
• Insulin Sensitivity

Interventions

Type	Name	Description
DRUG	Placebos	A 12 week single blind placebos
DRUG	metformin	A 12 week single blind metformin

Timeline

• Start date: 2014-06-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2015-12-17
• Last updated: 2020-03-23
• Results posted: 2020-03-23

Locations

1 site across 1 country: United States