NCT02616094

Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 224 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Extending previous findings, and applying a novel multi-method translational approach, this project hypothesizes that there are alcohol-related neuroendocrine and neural changes observable in acute and protracted abstinence, and which can accurately classify future relapse and treatment outcome in separate alcohol dependent (AD) patient samples, thereby validating them as biomarkers of relapse, with potential clinical utility as prognostic markers in identifying and treating those most susceptible to relapse.

Conditions

• Alcohol Dependence

Interventions

Type	Name	Description
DEVICE	Multi-method Neuroendocrine and Neuroimaging Procedure Scan 1	The MRI scan will be conducted on a 3-T Siemens Trio MRI system equipped with a standard quadrature head coil, using T1 MPRAGE sequence for structural scanning and T2\*-sensitive gradient-recalled single shot echo planar pulse sequence for functional scans. Two multimethod MRI scans will be conducted in the AD sample, while the controls will participate in a single scan.
DEVICE	Multi-method Neuroendocrine and Neuroimaging Procedure Scan 2	The MRI scan will be conducted on a 3-T Siemens Trio MRI system equipped with a standard quadrature head coil, using T1 MPRAGE sequence for structural scanning and T2\*-sensitive gradient-recalled single shot echo planar pulse sequence for functional scans. Two multimethod MRI scans will be conducted in the AD sample, while the controls will participate in a single scan.

Timeline

• Start date: 2015-11-01
• Primary completion: 2022-06-30
• Completion: 2022-06-30
• First posted: 2015-11-26
• Last updated: 2023-04-18

Locations

1 site across 1 country: United States