NCT02614027

Prevalence of Lipodystrophy Syndrome and Its Role as Cause of Metabolic Disturbances

Prevalence of Lipodystrophy Syndrome and Secondary Metabolic Syndrome in HIV-infected Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 276 (actual)
• Sponsor: Asociacion para el Estudio de las Enfermedades Infecciosas · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the prevalence of lipodystrophy syndrome in patients receiving currently available antiretroviral drugs, and the prevalence of associated metabolic syndrome in HIV-infected patients with a previous diagnosis of lipodystrophy syndrome, according to the severity of fat accumulation and antiretroviral drug use.

Detailed description

Cross-sectional evaluation of two groups of patients: * patients receiving currently available drugs, in order to determine the changes in fat accumulation by successive dual X-ray absorptiometry (DXA) determinations * patients with previous lipodystrophy syndrome, as evaluated by questionnaire (HOPS) and total body dual X-ray absorptiometry (DXA), in order to determine the prevalence of hypertension, low high density lipoprotein (HDL)-cholesterol, glucose disturbance (insulin resistance or diabetes), fat accumulation (waist circumference) and hypertriglyceridemia. The prevalence of Metabolic syndrome will be evaluated according to the different definitions (IDF, NCEP-ATP III, WHO).

Conditions

• Lipodystrophy
• Metabolic Syndrome

Interventions

Type	Name	Description
OTHER	Evaluation of metabolic syndrome	Evaluation and analytical determinations of the different components of the syndrome
OTHER	Evaluation of changes in fat by DXA while on current therapy	Comparison of changes in fat (visceral and subcutaneous) by dual X-ray absorptiometry since therapy initiation

Timeline

• Start date: 2016-02-01
• Primary completion: 2018-02-01
• Completion: 2018-06-01
• First posted: 2015-11-25
• Last updated: 2018-07-02

Locations

1 site across 1 country: Spain