NCT02612363

Early Goal Directed Sedation on Microcirculation in Septic Shock

The Effect of Early Goal Directed Sedation on Microcirculation in Septic Shock Patients With Mechanical Ventilation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients.

Detailed description

Recent studies suggest that early goal directed sedation might improve the outcome of critically ill patients. The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients with relative stable hemodynamics.

Conditions

• Septic Shock

Interventions

Type	Name	Description
DRUG	Dexmedetomidine for sedation	Dexmedetomidine or control drug for sedation * Analgesia * Propofol at lowest dosage. * Dose range: 0.1- 0.7 u/kg/hour * Target RASS score of -2 to +1 * Supplemental other sedatives at lowest effective dose

Timeline

• Start date: 2015-11-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2015-11-23
• Last updated: 2016-04-20

Locations

1 site across 1 country: China