NCT02609360

Effects of Different Crystalloid Solutions for Extra-corporeal Membrane Oxygenator (ECMO) Priming

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Crystalloid solutions modify acid-base equilibrium according to their electrolyte composition. Moreover, it has been suggested that these alterations are generated by the difference between the solution strong ion difference (SID) and the plasma bicarbonate level. An increased risk of acute kidney injury and renal replacement therapy has been associated to the infusion of chloride rich crystalloids. This study aims to compare, in patients with acute respiratory failure undergoing ECMO support, the effects on acid-base status and renal function of crystalloids commonly employed for circuit priming to a balanced solution created with a SID equal to patients' bicarbonate level.

Conditions

• Acute Respiratory Failure

Interventions

Type	Name	Description
OTHER	Priming of ECMO circuit with 0.9% NaCl	0.9% NaCl as priming crystalloid solution
OTHER	Priming of ECMO circuit with Ringer Lactate	Ringer Lactate as priming crystalloid solution
OTHER	Priming of ECMO circuit with Balanced Solution	Balanced Solution as priming crystalloid solution

Timeline

• Start date: 2013-05-01
• Primary completion: 2016-07-01
• First posted: 2015-11-20
• Last updated: 2015-11-20

Locations

1 site across 1 country: Italy