Trials / Completed
CompletedNCT02605681
Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis
Plasma Midkine Associated Organ Dysfunction and Vascular Injury in Sepsis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 26 (actual)
- Sponsor
- Southeast University, China · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ function, and also with plasma ACE and angiotensin II.
Detailed description
This study showed that Ang II induced endothelial injury in sepsis patients. Midkine has been shown to regulate the renin-angiotensin system and acts in the upstream signaling pathway of angiotensin (ANG) II. The investigators want to access the relationship between midkine level and ACE-Ang II induced endothelial injury in sepsis
Conditions
Timeline
- Start date
- 2016-11-01
- Primary completion
- 2018-03-31
- Completion
- 2018-06-15
- First posted
- 2015-11-16
- Last updated
- 2018-12-12
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT02605681. Inclusion in this directory is not an endorsement.