NCT02603939

Understanding Pain Perception in Osteoarthritis

Understanding Pain Perception in Osteoarthritis: a Mechanistic Study in People With Knee Osteoarthritis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: St George's, University of London · Academic / Other
• Sex: All
• Age: 35 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Osteoarthritis (OA)is a painful and disabling disease, predicted to be the fourth largest cause of disability worldwide by 2020. It commonly affects the hip or knee ultimately resulting in total joint replacement. In order to assess disease progression and plan surgery, x-rays are taken as part of routine practice. However x-rays provide limited information about formation of substructures and changes occurring during progression of disease. The proposed study aims to invite patients with OA of the hip or knee to participate in detailed examinations of their pain and their painful joint through interviews, blood and urine samples taken, MRI magnetic resonance imaging)and donating their waste tissue after joint surgery (all of old joint). Informed patient consent will be sought in all cases.

Detailed description

The patient will be asked for permission for a clinician to access their notes for information relevant to the research, including full medical history, their sex and date of birth. Tissue obtained from joint replacement surgery at St. George's Hospital and transferred to St.George's, University of London where it will be prepared for various experiments including looking at the genes and proteins in people with osteoarthritis. The blood and urine samples will also be taken to St. George's, University of London, and prepared for studies on the genes and proteins in people with osteoarthritis. All samples provided will be anonymised with no patient details on the samples and stored in locked freezers, in locked labs. at St.George's, University of London.

Conditions

• Osteoarthritis
• Pain

Interventions

Type	Name	Description
PROCEDURE	Joint replacement surgery	We are assessing pain responses in participants with osteoarthritis before an after joint replacement surgery

Timeline

• Start date: 2013-06-01
• Primary completion: 2021-12-01
• Completion: 2022-12-01
• First posted: 2015-11-13
• Last updated: 2020-10-26

Locations

1 site across 1 country: United Kingdom