NCT02594306

Brain Electrophysiological Study(EEG/ERP) on Opiate Addicts Treating by Bilateral NAc/ALIC Deep Brain Stimulation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Tang-Du Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Drug addiction is compulsive and spontaneous drug-taking behavior which is characterized by non-medical usage, long and repeated exposure to addictive drugs and gradually increasing drug-taking dosage and frequency,and become a main threat against human being's public health, economic development and social safety.

Detailed description

Effective treatments for severe drug addiction are limited. China centers employing compulsory detoxification, reported a 3 year abstinence rate of only 15%. For the methadone maintenance therapy, relapse often occurs promptly after cessation of methadone. A Malaysian reports about taking naltrexone or buprenorphine treating,showed average relapsed time of 2 or 3 months,respectively. Assessment for psychological craving degree of addiction patients is also a difficult thing.

Conditions

• Substance-Related Disorders

Interventions

Type	Name	Description
DEVICE	Emotional pictures stimulation system	Emotional pictures stimulation system is component of neutral and drug-related images.
PROCEDURE	Deep brain stimulation	Deep brain stimulation of bilateral NAc/ALIC
PROCEDURE	adjacent contact stimulation	The electrode of deep brain stimulation has four contacts.We stimulate one contact,and record the local field potential of other contacts.
PROCEDURE	microelectrode	We put the microelectrodes into bilateral nucleus accumbens and anterior limb of the internal capsule,to record the waveform of bilateral NAc/ALIC.

Timeline

• Start date: 2015-10-01
• Primary completion: 2016-11-01
• Completion: 2016-11-01
• First posted: 2015-11-03
• Last updated: 2016-02-19

Locations

1 site across 1 country: China