NCT02580240

Initiation of Hydrocortisone for the Treatment of Septic Shock

Early Initiation of Low-dose Hydrocortisone Treatment for Septic Shock in Adults: a Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 118 (actual)
• Sponsor: Northern Jiangsu People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.

Conditions

• Septic Shock

Interventions

Type	Name	Description
DRUG	Hydrocortisone	Hydrocortisone was administered 200 mg/d as a continuous infusion for 6d, then tapered off. Once all vasopressors were discontinued, the taper protocol was initiated (half dose for three days, then quarter dose for three days and then stopped).
DRUG	saline	Vials containing normal saline as placebo were identical to those containing hydrocortisone. Placebo administration procedures were similar.

Timeline

• Start date: 2015-09-01
• Primary completion: 2016-09-01
• Completion: 2016-12-01
• First posted: 2015-10-20
• Last updated: 2017-08-07
• Results posted: 2017-08-07

Locations

1 site across 1 country: China