NCT02579278

Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

This study does not involve randomization or treatment. Eligible patients have colorectal adenocarcinoma with no metastases eligible for curative surgery. A pre operative staging scan must have been completed within 6 weeks prior to surgery. Two x 20ml blood samples will be taken from each patient, one prior to and one during or within 24hrs after surgery. Patients are annually followed up to 3 years.

Detailed description

A multicentre observational study, ctDNA aims to provide the evidence base for metatstatic disease being caused by vascular methods of spread by determining if there is a link between EMVI status and ctDNA

Conditions

• Cancer
• Rectal Cancer

Interventions

Type	Name	Description
OTHER	Blood sample (mrEMVI positive patient)	Two blood samples are taken from each patient with mrEMVI positive tumours post chemoradiotherapy. One pre-surgery and one during surgery from a peripheral vein.
OTHER	Blood sample (mrEMVI negative patient)

Timeline

• Start date: 2015-11-01
• Primary completion: 2026-12-01
• Completion: 2029-12-01
• First posted: 2015-10-19
• Last updated: 2024-10-17

Locations

3 sites across 1 country: United Kingdom