NCT02552836

Efficacy of Psychotherapy for Depressed Parkinson's Disease Patients

Evaluation of Two Psychotherapies for Depressed Patients With Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Hopital Montfort · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of this randomized controlled trial is to determine the acute antidepressant efficacy of interpersonal psychotherapy (IPT) in depressed patients with Parkinson's Disease.

Detailed description

The primary aim of this study is to determine whether IPT is more efficacious than an intervention that controls for non-specific factors (i.e., supportive psychotherapy) in reducing depressive symptoms. A secondary aim is to determine whether IPT is better than supportive therapy in improving quality of life, interpersonal functioning, attachment patters, and motor symptoms, and whether treatment gains are durable at 6-months follow-up. An exploratory aim of the study is identify moderators and mediators of treatment outcome. Patients who meet study criteria will be randomly assigned to either 12 sessions of IPT or 12 sessions of supportive therapy. The primary efficacy measure (Hamilton Depression Rating Scale) will be administered at baseline, weeks 6 and 12, and at 6 months follow-up.

Conditions

• Depression
• Parkinson's Disease

Interventions

Type	Name	Description
BEHAVIORAL	Interpersonal Psychotherapy	A 12-week intervention that focuses on resolving interpersonal stressors that are linked to the onset, maintenance or exacerbation of depressive symptoms
BEHAVIORAL	Supportive Psychotherapy	A 12-week intervention that focuses on non-specific factors that contribute to therapy outcome

Timeline

• Start date: 2016-03-01
• Primary completion: 2023-03-01
• Completion: 2023-03-01
• First posted: 2015-09-17
• Last updated: 2024-03-19

Locations

2 sites across 1 country: Canada