NCT02552537

iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions

Integrated Approaches to Food Allergen and Allergy Risk Management: iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In patients with a walnut allergy double blind placebo controlled food challenge with walnut will be combined with the intake of proton pump inhibitor (PPI) or with placebo to assess the impact of PPI on threshold level and on clinical manifestation.

Detailed description

1. detailed case history, blood sampling and prick testing with different foods will performed. 2. double blind food provocation with with three meals containing either placebo or walnut in walnut allergic patients will be performed. 3. the provocation will be combined with the intake of drug (omeprazole) or placebo (mannitol) blinded in capsules.

Conditions

• Food Allergy

Interventions

Type	Name	Description
DRUG	Omeprazole	patients with walnut allergy will be exposed during 5 days before food challenge with Omeprazole
DRUG	Placebo	patients with walnut allergy will be exposed during 5 days before food challenge with Placebo

Timeline

• Start date: 2015-09-01
• Primary completion: 2017-03-01
• Completion: 2017-03-01
• First posted: 2015-09-17
• Last updated: 2017-05-11

Locations

2 sites across 2 countries: Spain, Switzerland