NCT02539745

Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Lv Yingjuan · Academic / Other
• Sex: All
• Age: 55 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma. Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.

Conditions

• Vitamin D Deficiency
• Primary Open- Angle Glaucoma

Interventions

Type	Name	Description
OTHER	Vitamin D receptor polymorphic analysis	Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.
OTHER	Serum levels of 1a, 25-Dihydroxyvitamin D3	Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay.

Timeline

• Start date: 2013-07-01
• Primary completion: 2014-12-01
• Completion: 2015-03-01
• First posted: 2015-09-03
• Last updated: 2016-04-22

Locations

1 site across 1 country: China