NCT02518633

Obstructive Sleep Apnoea and Adipose Tissue Dysfunction

Assessment of Hypoxia in Adipose Tissue of Subjects With Obstructive Sleep Apnoea

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: Royal Devon and Exeter NHS Foundation Trust · Academic / Other
• Sex: Male
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.

Detailed description

Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.

Conditions

• Obstructive Sleep Apnoea
• Obesity
• Hypoxia

Interventions

Type	Name	Description
DEVICE	Continuous positive airway pressure devices	overnight use of CPAP device

Timeline

• Start date: 2010-03-01
• Primary completion: 2015-03-01
• Completion: 2015-11-01
• First posted: 2015-08-10
• Last updated: 2017-02-17

Locations

2 sites across 1 country: United Kingdom