Trials / Completed
CompletedNCT02518347
Strawberries and Knee Osteoarthritis (OA)
Effects of Freeze-dried Strawberries on Systemic Markers of Inflammation and Knee Function in Participants With Osteoarthritis (OA)
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- Oklahoma State University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).
Detailed description
The investigators propose the following two specific aims in a randomized crossover placebo-controlled trial in participants with two or more features of the metabolic syndrome and symptomatic osteoarthritis in this 12-week efficacy study: Aim 1: To assess the effects of strawberries on biomarkers of inflammation \[serum levels of C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β; tumor necrosis factor-alpha: TNFα\] Aim 2: To assess the effects of strawberries on knee function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and HAQ-DI).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | FDS-Strawberry | Natural frozen and dried strawberries |
| DIETARY_SUPPLEMENT | Placebo | Placebo powder matched for carbohydrates and fiber in the strawberries |
Timeline
- Start date
- 2015-03-01
- Primary completion
- 2016-11-01
- Completion
- 2017-05-01
- First posted
- 2015-08-07
- Last updated
- 2018-01-18
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02518347. Inclusion in this directory is not an endorsement.