NCT02512978

Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)

Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Based on accumulating evidences showing that hypothyroid status is associated with poor prognosis among acute myocardial infarction (AMI) patients, the study is designed to evaluate whether replacement treatment with levothyroxine could have beneficial effects on patients with AMI and hypothyroidism. This is a multicenter prospective computerized-randomized trial stratified by ejection fraction with a 1:1 ratio to levothyroxine group or standard therapy group.

Detailed description

The primary hypothesis is that reversing the hypothyroid status with levothyroxine on top of standard therapy for AMI is safe and has beneficial effects on cardiac function, myocardial perfusion/metabolism and myocardial fibrosis.

Conditions

• Myocardial Infarction
• Hypothyroidism

Interventions

Type	Name	Description
DRUG	Levothyroxine	Levothyroxine is used to normalize the thyroid hormone level of patients allocated to levothyroxine.

Timeline

• Start date: 2015-08-01
• Primary completion: 2018-12-01
• Completion: 2019-06-01
• First posted: 2015-07-31
• Last updated: 2018-07-16

Locations

1 site across 1 country: China