NCT02504125

The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty

The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty: a Randomized, Double-blind, Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

A randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty.

Detailed description

A randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty. Subjects will be monitored for occurrence of any complications, particularly deep venous thrombosis and thromboembolism during the hospital stay and for 1 months postoperatively.

Conditions

• Blood Loss

Interventions

Type	Name	Description
DRUG	Tranexamic Acid	1 g of tranexamic acid in 100 mL of normal saline intravenously approximately 15 minutes before incision
DRUG	Normal saline	100 mL of normal saline intravenously approximately 15 minutes before incision

Timeline

• Start date: 2013-01-01
• Primary completion: 2014-06-01
• Completion: 2015-06-01
• First posted: 2015-07-21
• Last updated: 2016-03-04

Locations

1 site across 1 country: China