NCT02500069

Location Specific Differences in Intestinal Brake Activation

The Effect of Intestinal Brake Activation at Different Locations in the Gut on Food Intake and Hormone Release

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The appearance of intact macronutrients in the small intestine can result in the activation of an intestinal brake; a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to the central nervous system. These processes inhibit food processing, appetite sensations and food intake, and furthermore they increase feelings of satiety and satiation. The researchers will investigate the effects of intraduodenal, intrajejunal and intralileal infusion of casein (protein) on ad libitum food intake, satiation and in vivo release of the gut satiety peptides CCK, PYY and GLP-1 and glucose and insulin.

Conditions

• Ileal Brake
• Satiety
• Overweight
• Obesity
• Overeating

Interventions

Type	Name	Description
OTHER	placebo	infusion of tap water in all regions (duodenum, jejunum and ileum)
OTHER	Casein (in duodenum)	infusion of protein in duodenum
OTHER	Casein (in jejunum)	infusion of protein in jejunum
OTHER	Casein (in ileum)	infusion of protein in ileum

Timeline

• Start date: 2014-05-01
• Primary completion: 2014-12-01
• Completion: 2015-03-01
• First posted: 2015-07-16
• Last updated: 2015-07-16

Locations

1 site across 1 country: Netherlands