NCT02473718

Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU. The study will also determine if decreasing overall fluids can decrease adverse events associated with mechanical ventilation, such as ventilator-associated pneumonias. The protocol will include daily ultrasounds and blood draws to evaluate fluid balance. Ultrasound will be used to measure changes in the diameter of the inferior vena cava with respiration.

Conditions

• Septic Shock
• Fluid Therapy
• Hypotension

Interventions

Type	Name	Description
OTHER	Fluid minimization protocol	Fluid nonresponsive patients will have continuous infusions concentrated, maintenance fluids discontinued, and carrier fluids minimized. Diuretics and/or ultrafiltration will be utilized to maintain an even to negative fluid balance in patients demonstrating fluid non-responsiveness.
DEVICE	Ultrasound

Timeline

• Start date: 2014-01-01
• Primary completion: 2014-12-01
• Completion: 2015-01-01
• First posted: 2015-06-16
• Last updated: 2024-07-24
• Results posted: 2018-03-29