NCT02467231

Ovarian Reserve After Cancer: Longitudinal Effects

Ovarian Reserve After Cancer: Longitudinal Effects A Multicenter Prospective Cohort Study by the Oncofertility Consortium

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 196 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: Female
• Age: 11 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Women of reproductive age who will receive treatment for cancer that includes chemotherapy may participate in a study measuring ovarian function over time. Eligible women are asked to complete a questionnaire, a menstrual diary, a brief physical examination, an ultrasound, and a blood test before, during and after cancer treatment.

Detailed description

A total of 7 study visits will be completed at 3 month intervals including 1 visit prior to treatment, and at least 2 visits after completion of treatment. Duration of study participation is 18-30 months, depending on length of treatment. Review and Documentation of Cancer Therapy will be abstracted from the clinical oncology chart by the oncology offices caring for the patient. Treatment will be summarized in terms of chemotherapeutic type, duration and cumulative dose; total radiation dose and location; history and type of bone marrow transplantation; and any surgery. Any attempts at fertility preservation or use of gonadotropin releasing hormone agonist treatment during cancer therapy will be captured as well.

Conditions

• Effects of Chemotherapy
• Premature Ovarian Failure

Timeline

• Start date: 2009-02-01
• Primary completion: 2028-04-01
• Completion: 2028-12-01
• First posted: 2015-06-09
• Last updated: 2025-10-28

Locations

1 site across 1 country: United States