NCT02447315

A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects

A Phase 1 Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Astellas Pharma Europe B.V. · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the pharmacodynamic effect of oral doses of pilocarpine on salivary secretion in healthy male and female subjects. In addition, pharmacodynamic effect on static pupillometry will be evaluated as well as pharmacokinetics and safety and tolerability of oral doses of pilocarpine in healthy subjects.

Conditions

• Healthy Subjects

Interventions

Type	Name	Description
DRUG	Pilocarpine	oral
DRUG	Placebo	oral

Timeline

• Start date: 2015-05-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2015-05-18
• Last updated: 2015-08-13

Locations

1 site across 1 country: United Kingdom