NCT02430272

Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: Inje University · Academic / Other
• Sex: All
• Age: 12 Months – 8 Years
• Healthy volunteers: Not accepted

Summary

Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents. The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.

Conditions

• Fever

Interventions

Type	Name	Description
DRUG	Glycopyrrolate	Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group

Timeline

• Start date: 2014-05-01
• Primary completion: 2014-11-01
• Completion: 2014-12-01
• First posted: 2015-04-30
• Last updated: 2015-05-01

Locations

1 site across 1 country: South Korea