NCT02426164

Liposomal Bupivacaine in Total Knee Arthroplasty

Analgesic Efficacy of Liposomal Bupivacaine in Total Knee Arthroplasty

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Miller Orthopedic Specialists · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief. Despite its long-acting analgesic potential, liposomal bupivacaine is significantly more expensive than other local anesthetic alternatives. The primary aim of this investigation is to examine whether or not liposomal bupivacaine provides superior pain relief or clinically significant opioid-sparing effects versus a control to justify its cost.

Conditions

• Pain, Postoperative
• Arthroplasty, Replacement, Knee
• Osteoarthritis

Interventions

Type	Name	Description
DRUG	Liposomal bupivacaine	Periarticular infiltration of the liposomal bupivacaine with 20cc of normal saline
DRUG	bupivacaine HCl, morphine, epinephrine, methylprednisolone	Periarticular infiltration of 24c of bupivacaine HCl, 0.8cc morphine, 0.3cc epinephrine, and 1cc of methylprednisolone

Timeline

• Start date: 2015-06-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2015-04-24
• Last updated: 2016-03-22

Locations

1 site across 1 country: United States