NCT02421614

Enteral Feeding Composition and Acute Respiratory Failure

Effect of Enteral Feeding's Macronutrient Composition on Inflammatory Mediators, Oxidative Stress and Outcomes in Intensive Care Unit Patients With Acute Respiratory Failure

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Zahra Vahdat Shariatpanahi · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to investigate the effect of enteral feeding's macronutrient composition on inflammatory mediators, oxidative stress and outcomes in Intensive Care Unit (ICU) patients with acute respiratory failure. In this double-blind randomized control trial, 42 patients of both sexes and diagnosed with acute respiratory failure in ICU that receive enteral feeding, will be randomly assigned to three groups of 14 each. First Intervention group; high-protein low-carbohydrate diet with high olive oil, the second intervention group; high-protein low-carbohydrate diet with high sunflower oil and control; high-protein kitchen formula. Intravenous levels of uric acid, high sensitive C-Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Total Antioxidant Capacity (TAC) measured at days 0 and 10. As well as, organ failure, duration of ventilation, length of ICU stay and mortality rates will be evaluated.

Conditions

• Acute Respiratory Failure

Interventions

Type	Name	Description
OTHER	high-protein low-carbohydrate diet with high olive oil
OTHER	high-protein low-carbohydrate diet with high sunflower oil

Timeline

• Start date: 2013-08-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2015-04-20
• Last updated: 2016-03-22

Locations

1 site across 1 country: Iran