NCT02420834

Dry Eye Treatment With Artificial Tears

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Aston University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Dry eye is a chronic irritating eye condition that affects many people, caused by poor tear quality and insufficient quantity. Treatments are traditionally in the form of artificial tears applied to the ocular surface. However, there is little evidence in the scientific literature that demonstrates their efficacy relative compared to each other, nor how to decide which one might be most effective for an individual patient. Therefore the investigators aim to examine the efficacy of different classes of artificial tears (those designed to increase viscosity, reduce evaporation or to mimic the component balance of the natural tears). In addition, the investigators also aim to determine how the treatment preferred by an individual could potentially have been predicted from their baseline condition.

Detailed description

The efficacy of different classes of artificial tears (non-pharmaceutical) will be examined in patients that report dry eyes by prescribing each category of treatment \[0.40% Sodium Hyaluronate (Clinitas Soothe), 0.15% Sodium Hyaluronate (Hyabak), 0.25% Carboxymethylcellulose, electrolyte balanced (Theratears), and Phospholipid liposomal spray (Tears Again)\] for a month in turn following a short wash-out period and to examine their tear film and ocular surface after each one.

Conditions

• Dry Eye

Interventions

Type	Name	Description
OTHER	Hypromellose 0.15%	Tear supplement to be taken as required to relieve symptoms
OTHER	Hypromellose 0.4%	Tear supplement to be taken as required to relieve symptoms
OTHER	Carboxymethylcellulose	Tear supplement to be taken as required to relieve symptoms
OTHER	Liposomal Spray	Tear supplement o be taken as required to relieve symptoms

Timeline

• Start date: 2015-04-01
• Primary completion: 2019-01-01
• Completion: 2019-01-01
• First posted: 2015-04-20
• Last updated: 2019-01-10

Locations

1 site across 1 country: United Kingdom